Abstract The coronavirus disease 19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to a global health Perches Plastic crisis with millions of confirmed cases and related deaths.The main protease (Mpro) of SARS-CoV-2 is crucial for viral replication and presents an attractive target for drug development.Des
TRP channels and G protein-coupled receptors (GPCRs) play critical roles in sensory reception.However, the identities of the chaperones that assist GPCRs in translocating from the endoplasmic reticulum (ER) are limited, and TRP ER chaperones are virtually unknown.The one exception for TRPs is Drosophila XPORT.Here, we show that the xport locus is b
Darcy Gillis,1 Jillian Demmons,1 Graeme Rocker1,2 1Division of Respirology, Department of Medicine, Queen Elizabeth II Health Collections Sciences Centre, Nova Scotia Health Authority, Halifax, NS, Canada; 2Division of Respirology, Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada Background: The Halifax-based INSPIRED COPD Ou
Previous research suggests climate warming during the current century is likely to lead to an increase in the frequency and severity of wildfire.Recent wildfire seasons in northern Canada generally support these studies, with some of the worst fire seasons on record occurring during the past decade.While we can readily track the spatial and tempora